We bought a laser engraving machine at work. Althought it will cut a variety of materials, it cuts acrylic especially well. I slapped together a simple iPod dock using it. It is basically three 1/4" acrylic pieces assembled using stainless-steel press-fit pins in each corner.
The top piece has a cutout to accomodate the standard iPod dock adapter that comes with every iPod.

The middle piece has a slot cut so a standard iPod docking cable slides in. This cut needed to be made on an angle. This angle cut was made by propping up one side the acrylic piece while laser cutting it.

The bottom piece has a slot cut to allow the docking cable cord to lay in.

Pretty simple, eh? This is just a prototype that took me about 1/2hr to design, cut and assemble. I'll probably put a few of these together for some co-workers.

If anyone wants detailed drawings, lemme know and I'll post them. Although I used a CO2 laser engraving machine, this could be made easily using a standard mill, or even a drill and saw.